|
KMID : 0892920200290020138
|
|
Experimental Neurobiology
2020 Volume.29 No. 2 p.138 ~ p.149
|
|
|
Loss of MicroRNA-137 Impairs the Homeostasis of Potassium in Neurons via KCC2
|
|
Mi Ting-Wei
Sun Xiao-Wen
Wang Zhi-Meng
Wang Ying-Ying
He Xuan-Cheng
Liu Cong
Zhang Shuang-Feng
Du Hong-Zhen
Liu Chang-Mei
Teng Zhao-Qian
|
|
|
Abstract
|
|
|
|
Neuropsychiatric disorders are the leading cause of mental and intellectual disabilities worldwide. Current therapies against neuropsychiatric disorders are very limited, and very little is known about the onset and development of these diseases, and their most effective treatments. MIR137 has been previously identified as a risk gene for the etiology of schizophrenia, bipolar disorder, and autism spectrum disorder. Here we generated a forebrain-specific MIR137 knockout mouse model, and provided evidence that loss of miR-137 resulted in impaired homeostasis of potassium in mouse hippocampal neurons. KCC2, a potassium-chloride co-transporter, was a direct downstream target of miR-137. The KCC2 specific antagonist VU0240551 could balance the current of potassium in miR-137 knockout neurons, and knockdown of KCC2 could ameliorate anxiety-like behavior in MIR137 cKO mice. These data suggest that KCC2 antagonists or knockdown might be beneficial to neuropsychiatric disorders due to the deficiency of miR-137.
|
|
|
KEYWORD
|
|
|
MIR137, KCC2, Anxiety, Potassium
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
  
|